Brettles02,
Could you clarify about the misfire is it a complete cylinder misfire that can be felt at idle or one that only takes place in certain conditions?
If it is a dead hole you could do a low tech cylinder kill. There is some risk involved both to equipment and person. The process is to use a back probe inserted into one ignition cable at a time. Then using a jumper lead ground the cylinder.
IF NOT DONE RIGHT IT WILL SHOCK YOU. IF NOT DONE RIGHT IT COULD DAMAGE EQUIPMENT. So be careful if you try it.
The idea is with a cylinder not contributing there will be no engine speed drop on the bad cylinder. The problem is if it is a partial misfire it will not work as well especially if the miss is not at idle.
Have you replaced any GM fuel pumps with in tank pressure sensor?
If you have you have a low cost pulse sensor for the exhaust you can build yourself. That is of course additional equipment you would need to fabricate.
The technique with the least effort would be to observe secondary ignition. Based oh the post I am assuming you do not have a DIS adapter such as the Mixmaster or the Ferret. You should have at 2 or four KV probes that came with your scope. Connect the two probes to the two coil towers and duplicate the symptom. Do this two times if you have 4 probes or 3 times if you only have two.
So you will be connecting to 1/4, 2/5, 3/6 if that is similar to a Buick V6.
I am posting a link to a video I uploaded on Google video some time ago. It was from a Ford, although it should give you an example of what the set up is. I also used Pico Diagnostics. I did not mention that because there is not a good way to determine the cylinder that is missing through Pico diagnostics. at this time. The video clip I posted had a broken spark plug, I suspect from a head gasket leak.
Here is the video:
Once you record you files with the misfire present post the psd files here and we will try to help further.
Good luck
Sam